Product Description
An efficient and reliable enzymatic tool for research on antibody-based drugs and Fc fusion proteins. IdeS Protease (Immunoglobulin G-degrading enzyme) is a cysteine endopeptidase secreted by Streptococcus pyogenes, known for its exceptional substrate specificity. It cleaves IgG at a specific site within the hinge region, hydrolyzing it into intact F(ab')2 fragments and Fc fragments.
Product Advantages
- High Purity: Soluble, high-yield expression with low host protein residues; purity >95%.
- Superior Cleavage Performance: Suitable for structural characterization of therapeutic antibodies, Fc fusion proteins, and antibody-drug conjugates.
- High Enzyme Activity: Activity >40 U/μL, specifically cleaving IgG antibodies to obtain targeted fragments.
- Animal-Free: Recombinant expression with no animal-derived raw materials used, ensuring no risk of exogenous viral contamination.
Applications
- Structural characterization of therapeutic antibodies
- Functional analysis of Fc fusion proteins
- Characterization of antibody-drug conjugates
- Development of antibody-based drugs
Product Details
| Attribute | Details |
|---|---|
| Product Name | IdeS Protease |
| Product Alias | Immunoglobulin G-degrading enzyme |
| Catalog Number | ATE00010 |
| Storage | Store at -20°C; shelf life 12 months |
| Shipping | Shipped on blue ice |
| Form | Liquid |
| Storage Buffer | PBS (pH 7.4), 50% glycerol |
| Host | E. coli |
| Molecular Weight | 37.56 kDa |
| Purity | >95% (by SDS-PAGE) |
| Activity | 40 U/μL |
| Specific Activity | 40000 U/mg |
| Reaction Conditions | 37°C for 30 minutes |
| Tag | N-terminal His Tag |
About AtaGenix Laboratories
AtaGenix lab's IdeS Protease, developed using advanced recombinant expression and purification technologies in E. coli, ensures high purity and activity. It is widely applied in antibody drug development and research, making it an ideal choice for characterizing therapeutic antibodies and antibody-drug conjugates.
Choose AtaGenix Laboratories to drive innovation in research!
