Product Description
AtaGenix offers high-purity IdeZ Protease, an efficient and reliable enzymatic tool for studying antibody-based drugs and Fc fusion proteins. IdeZ Protease (Immunoglobulin G Degrading Enzyme) is a protease derived from Streptococcus equi subspecies zooepidemicus, known for its exceptional substrate specificity. It cleaves IgG at a specific site in the hinge region, generating intact F(ab’)2 fragments and Fc fragments.
Product Advantages
- High Specificity: Specifically cleaves IgG, compatible with human IgG1, IgG2, IgG3, IgG4, and monkey, sheep, rabbit, humanized, and chimeric IgGs.
- Broad Compatibility: Compared to IdeS protease, IdeZ shows enhanced activity against mouse IgG2a and IgG3, making it suitable for a wider range of applications.
- Superior Performance: Ideal for characterizing therapeutic antibodies, Fc fusion proteins, and antibody-drug conjugates, providing reliable experimental support.
- High Purity and Stability: Produced via recombinant E. coli expression with >95% purity, free of impurities, and high stability.
Applications
- Structural characterization of therapeutic antibodies.
- Functional analysis of Fc fusion proteins.
- Antibody-drug conjugate (ADC) studies.
- Antibody-based drug development.
Product Specifications
| Attribute | Details |
|---|---|
| Product Name | IdeZ Protease |
| Catalog Number | ATE00014 |
| Form | Liquid |
| Storage Conditions | Store at -20°C, shelf life: 12 months |
| Shipping | Shipped on blue ice |
| Buffer | PBS (pH 7.5), 50% glycerol |
| Host Expression | Recombinant E. coli |
| Molecular Weight | 38 kDa |
| Purity | >95% (validated by SDS-PAGE) |
| Activity | 50 U/µl |
| Reaction Conditions | Cleavage at 37°C for 30 minutes |
| Tag | N-terminal His Tag |
About AtaGenix
AtaGenix uses advanced recombinant E. coli expression and purification technology to ensure the high purity and activity of IdeZ Protease, making it a trusted tool for antibody drug development and research. Our product is the ideal choice for characterizing therapeutic antibodies and antibody-drug conjugates.
Choose AtaGenix to accelerate your research and innovation!
